Click the plus + button to add a row to the list.

To remap the key for this use, pop open PowerToys Settings and head to the Keyboard Manager, click Remap a Key, and then: I can quickly reach out and mute/unmute myself during calls and meetings without any delay, switching programs, or grabbing my mouse and aiming at the actual mute button on the screen. I picked Scroll Lock myself because I never ever use it and because it’s easy to find by touch on my particular keyboard. Other oft-unused keys like Pause, Insert, or even Caps Lock are prime for repurposing into an easy mute toggle. Or the Print-Screen key, which has already taken a back-seat to Win-Shift-S. The F1 key, for example, could easily be repurposed from its day job of opening a bing search. Maybe you are like me and have a key or two on your keyboard that you can repurpose for this task. Thankfully, using PowerToys keyboard manager we can set the mute shortcut to anything we please - even a single button. I don’t blame the shell team, it’s not their fault that all the good keyboard shortcuts have been claimed over the decades, but the Win+Alt+K is just not quick and easy to me. Unfortunately, the keyboard shortcut for it is a bit unwieldy.

Windows 11 includes a universal mic button on the taskbar, allowing you to mute or unmute quickly and without switching to your meeting app.

Skype for business mute hotkey